Assessment of Enzymatic and non-enzymatic markers in Oral cancer

Abstract

Oral cancer is a malignant neoplasia that develops on the lip or in the oral cavity, commonly referred to as squamous cell carcinoma (OSCC) as 90% of malignancies in the dental area have squamous cell origins ^[1]. Although there has been a rise in oral cancer diagnoses among those under 40, the disease's incidence rises with age, reaching its peak in those over 60. The present study aimed to  estimate the levels of Sialic acid, LDH and ALP in the given serum sample and to determine the role played by Sialic acid, LDH and ALP in oral cancer.  The study group consists of 30 control groups with no complications and 30 oral cancer patients. 5ml venous blood sample was taken, centrifuged and serum was collected . Serum was analyzed for LDH, ALP and Sialic acid. The mean age of the study population, the case group was 50.25±10.58 and the control group was 26.2±1.28. Males were 80% and Females were 20 % in the case group and in the control groups, males and females were 50% each. Most of the patients had the habits of smoking, alcohol consumption and tobacco chewing. Significantly higher levels of LDH, ALP and Sialic acid was observed in the serum of Oral cancer patients. ALP, LDH and sialic acid may be considered sensitive markers for the diagnosis of dysplasia with precancerous and malignant lesions. As a result, it can aid with the early diagnosis of oral carcinoma.