Correlation between the Glucose, BMI and metalions in Type II Diabetes Mellitus
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Abstract
Type 2 Diabetes Mellitus (T2DM) is a common metabolic condition caused by inadequate insulin release by pancreatic β-cells and the inability of insulin-sensitive tissues to respond. Obesity is the leading risk factor for T2DM and is linked to metabolic abnormalities that cause Insulin Resistance. Traditional risk factors, such as inheritance and poor dietary habits, cannot fully explain the etiology and high prevalence of diabetes mellitus. Metal exposure is a new and emerging risk factor that is gaining attention. Heavy metals can disrupt mitochondrial processes and increase free radical generation, resulting in oxidative stress and inflammation, both of which may have a role in metabolic disorders such as diabetes mellitus or obesity. In the present study, we aim to check whether there is any correlation between metal ions, glucose, Body mass index (BMI) in patients with T2DM. 50 healthy normal control, diabetic patients with controlled Blood Sugar Level - 50 Subjects and diabetic with Uncontrolled Blood Sugar Level - 50 Subjects were included in the study. A significantly elevated level of blood sugar and BMI was observed in the Type 2DM group. A significantly elevated level of copper and lead was observed in the Type2 DM and a slightly decreased (significant) level of zinc was observed in the Type2 DM case. A low-carbohydrate ketogenic diet can reduce hyperglycemia, hyperinsulinemia, insulin resistance, and type 2 diabetes.
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