Study of Methylenetetrahydrofolate Reductase C677T gene polymorphism and some biochemical markers for patients with hypertension

Abstract

The study aims to evaluate the levels of some biochemical in hypertension patients, find out 
MTHFRC677T gene polymorphism exist, and whether they are a risk factor for hypertension. 
This case-control study, included 120 participants, the biochemical analyses were measured by 
ELISA technique. Genetic analysis was performed by Tetra ARMS-PCR, Chi-square and odds 
ratio used for data analysis. The study found an increase in the level of homocysteine; a decrease 
in the levels of MTHFR and vitamin B12; a non-significant difference in folic acid levels in 
hypertension patients without treatment when compared with controls. There is a non-significant 
difference in the levels of this markers in patients on angiotensin receptor blocker (ARBs) 
valsartan drugs when compared with hypertension patients without treatment. In MTHFRC677T
gene polymorphism, the most prevalent genotype is CT (56%), CC, and TT with (32%) and 
(12%) for each of them in succession with OR of 1.18 ,the T allele is present (40%) in case 
group and (24%) in control group. In conclusion, hyperhomocysteinemia decrease in the levels 
of MTHFR enzyme and vitamin B12 may be one of the underlying cause of hypertension, there
is no relationship between the level of folic acid in serum and hypertension.